Cocaine, Marijuana & Weight Loss Diet Pill Review
What Do Cocaine & Marijuana Have to Do with Weight Loss?
Everything. Now I am not endorsing the use of cocaine and marijuana to facilitate weight loss. What I am endorsing is the use of legal substances that stimulate the Cocaine Amphetamine Regulatory Transcript (CART) and inhibit Neuropeptide-Y (NPY).
Cocaine and amphetamines have been proven to send the CART hormone into hyper drive.
When CART is activated it:
- Increases your metabolism
- Reduces your appetite
- Increases insulin to shuttle energy to your muscles instead of storing it as body fat.
Marijuana has been clinically proven to suppress NPY. NPY is a Stress Hormone that drives the eating chemicals into hyper drive. When it is stimulated it will:
- Decrease your metabolism (the rate at which you burn fat)
- Cause your body temperature to drop
- And increases your appetite.
The Cocaine Research the Feds Don’t Want You to See
In the mid-’80s America’s poorer urban neighborhoods slowly began unraveling as a new and more deadly drug hit the streets: crack. An even more potent form of powdered cocaine, crack was found to be more addicting, and the street life that surrounded its use led to a whole new type of addict, one even more difficult to treat. The federal government took notice and a renewed emphasis was placed on understanding this drug and on finding a treatment.
In 1995 researchers at the Vollum Institute in Oregon noticed that cocaine-drugged rats produced an increased level of a messenger RNA (mRNA) in the brain. In cells, DNA is copied into mRNA form, and RNA is then copied into a protein or peptide form–the final product of the DNA message. Knowing this, researchers wondered if the mRNA they had discovered might be the cause of cocaine’s effects. They called their finding CART, for cocaine and amphetamine regulated transcript.
“It was postulated that the product of CART, the peptide, would be involved in the action of cocaine amphetamine. If the precursor (mRNA) goes up, there must be demand for the product (peptide),” said Yerkes researcher and Georgia Research Alliance Eminent Scholar Michael Kuhar.
Kuhar has been studying cocaine for years, trying to find a medication to counter its ill effects. He became interested in CART and began his research by asking three questions: Is CART made in the brain? Are these parts of the brain the same parts involved in addiction? Does CART peptide affect the body?
To begin his research Kuhar collaborated with Neurocrine Corp. to derive CART peptide antibodies that would bind to the peptide and allow him to see where and when the protein was being produced. The antibodies showed that cocaine-injected rats produced high CART levels in brain areas involved in drug addiction.
Next he injected rats with the CART peptide. Like the rats given cocaine, these animals showed increased activity and a lack of hunger. In short, the answer to all three of his questions was yes. But the study’s results had even more interesting applications. “Drugs that affect CART may be useful in treating eating disorders,” said Kuhar.
Kuhar’s lab found CART in the hypothalamus, the area of the brain that controls a number of physiological processes, including food intake. And results from the feeding study found rats consuming about 30 percent less food than rats not given the CART peptide.
“Because of the serious problem of obesity in some parts of the world, there is a huge market for anti-obesity drugs,” Kuhar said. Because of this many companies have gotten excited about the CART peptide. One Danish company has begun conducting trials on CART, and several large American drug companies are starting similar ventures.
These studies may also lead to therapy for anorexia as well, since turning off CART might increase hunger.
Meanwhile, Kuhar has begun to focus on locating the receptor for the CART peptide and in discovering CART agonists and antagonists–agonists mimic the effects of a substance while antagonists block them. Unlike the CART peptide, these therapeutic drugs will be taken orally. CART cannot be taken orally because, like most proteins, it is broken down in the digestive track.
Kuhar said he remains uncertain as to what the studies on CART will reveal next. But he is excited about the possibilities, adding that CART may even be involved in stress-related disorders as it also is found in areas of the brain involved in stress.
When CART is stimulated it increases your metabolism, reduces your appetite, and increases insulin to deliver energy to your muscles rather than be stored as body fat. NPY is a stress hormone that drives the eating chemicals into overdrive.
Here are some popular herbal CART Activators and Neuropeptide-Y inhibitors:
C-A-R-T Activators
- Amphetamines – Prescription amphetamines have been used for short periods of time in weight-control programs to suppress appetite and to treat narcolepsy. Amphetamines can produce severe systemic effects, including cardiac irregularities and gastric disturbances. Chronic use often results in insomnia, hyperactivity, irritability, and aggressive behavior.
- Phentermine – A drug that suppresses appetite by altering the body’s metabolism of the neurotransmitters serotonin and norepinephrine, used in the management of obesity.
- Fenfluramine – An appetite suppressant, chemically related to amphetamine, but without its addictive properties. Fenfluramine is used in the treatment of obesity. Because of its adverse side-effects including depression and irregular heart beats, it was pulled from the market.
- Cocaine - Cocaine is the most potent stimulant of natural origin. It is of course illegal. Doctors say cocaine acts as an appetite suppressant to such an extent that it can make users vulnerable to malnutrition. Long-term use can result in a range of mental health conditions from mild depression to the extremes of cocaine psychosis with symptoms similar to schizophrenia.
- DiCaffeine Malate – an ultra potent multi-dimensional ingredient that combines all natural Caffeine with Malic Acid into an ionic bonded compound optimizing energy, stimulating thermogenesis, and promoting mental focus.
- Phenylethylamine (PEA) – PEA has arousal properties similar to catecholamines and may be one of the pleasure substances in the brain. It is extracted from chocolate and is responsible for what chocaholics call “Chocolate High”.
- Synephrine HCl – can help burn fat, suppress appetite and increase energy. Synephrine HCl is derived from the Citrus aurantium fruit, which is used for a variety of purposes in traditional Chinese medicine.
- 1,3 Dimethylamylamine (DMAA) – resembles the body’s chemical messenger epinephrine, also known as adrenaline. Like adrenaline, 1,3-Dimethylamylamine is a powerful stimulant, that suppresses appetite, burns fat, boosts energy and increases physical performance. For fat loss, 1,3-Dimethylamylamine works by causing a rise in cAMP, the chemical messenger that triggers fat release.
- Evodiamine 98% – Several studies have shown that it reduces both fat uptake and burns the fat inside the body. Thermodiamine appears to support an increase in lipolytic (fat burning) activity through several mechanisms. Evodiamine appears to affect receptors known as vanilloids. These receptors are involved in the regulation of body temperature.
- Sclareolide 98% – This supplement has excellent thermogenic properties and is used to aid in weight loss. It supports an increase in the rate of lipolysis (fat burning) activity through Cyclic AMP. Cyclic AMP is an integral part of energy metabolism and can help the body produce more energy through the breakdown of fat stores and thermogenesis.
NP-Y Inhibitors
- Chocamine – naturally contains Tryptophan – an amino acid that increases brain levels of serotonin and is commonly used to combat stress and depression.
- Marijuana – Evidence regarding the robust effect of the recreational drug marijuana (Cannabis sativa) on appetite and food intake has been widely known for centuries. Current studies, in conjunction with the fact that cannabinoid receptor antagonist compounds are currently in clinical trials as antiobesity drugs in Europe, raise the hope that Marijuana could be successful in the treatment of obesity.
- Humulus lupulus is unique because it is one of only two plants in the family Cannabinaceae. The alkaloid extract in Humulus Lupus known as Lupulinum produces a mild stimulant effect at first, followed by a very agreeable, calming sensation… the perfect combination. Historically, it has been used in some cases of nervous irritability where opium/narcotics failed. Some say that Humulus Lupus has some anti-inflammatory/pain relieving capabilites
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Below are the two diet pills with the highest consumer ratings. Enjoy the fruits of our research, but please remember to come back to DietPills.org and leave your feedback for future consumers!
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