Amberen isn’t a typical diet pill.
Instead, Amberen is advertised as a “smart choice for menopause.” It offers relief from hot flashes, weight gain, sleeplessness, irritability, and low libido triggered by menopause.
Amberen also comes highly recommended by doctors Brenda McCool, David Stoeber, and Ella Fedonenko, but is it a reliable solution?
Let’s find out together. . . .
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The Scoop on Amberen Ingredients
A quick glance at the label can be a bit intimidating. All those scientific looking names crammed together can make Amberen look like rocket science.
Fortunately, Amberen manufacturers provide consumers with in-depth ingredient descriptions.
Ammonium Succinate. Succinate, or succinate acid, is formed during the krebs cycle (the aerobic energy system that breaks down fats and carbs). Animal studies suggest it alleviates menopausal symptoms. 
Calcium Disuccinate. An easy-to-digest form of calcium, calcium disuccinate reduces osteoporosis risk. It treats premenstrual and menopausal symptoms. For women between the ages of 19-70, the DA (dietary association) recommends taking 1000 mg to 1200 mg daily.
Monosodium L-Glutamate. Glutamine is an amino acid that builds muscle, boosts immunity, and improves the digestive system. Monosodium L-Glutamate is the salt of this amino acid. It regulates transamination chemical reactions (reactions between two molecules), potentially stabilizing energy levels. It is on the FDA list of GRAS (generally recognized as safe) substances. 
Glycine. Glycine is a nonessential amino acid and building block of protein. It also plays a key role in neurotransmission. Some researchers think glycine may improve memory and treat schizophrenia.
Magnesium Dissucinate Hydrate. An easily absorbed form of magnesium, it is involved in over 300 chemical reactions. It may reduce migraine frequency and severity, decrease osteoporosis risk, and alleviate premenstrual and menopausal symptoms. The DA recommends 310 mg to 320 mg for adult women.
Zinc Difumarate Hydrate. A combination of zinc and fumarate, this compound boosts immunity, stimulates tissue repair, and improves memory.
Tocopherol Acetate. More commonly known as vitamin E, this ingredient protects cells from oxidative stress. It may relieve premenstrual and menopausal symptoms.
Keep in mind that these ingredients were chosen to treat menopause. Since weight fluctuation is a menopause side effect, this supplement may stabilize your weight. On the other hand, that is not the main purpose of this pill, so don’t expect extreme results.
Is there Research?
With such a unique blend of vitamins, minerals, and other ingredients crammed in Amberen, it’s only natural to wonder if these ingredients actually work.
Interestingly enough, Amberen.com claims to have been “clinically tested and extensively studied for over 30 years,” but the product itself didn’t come out until 2005.
Just how exactly is this possible?
Amberen gets its name from its main ingredient: succinate acid, formally known as amber acid. This ingredient was originally studied back in 1971 as a menopausal treatment in mice. If Amberen manufacturers lump all the ingredient studies alongside their product studies, they can justify their claims for decades of research.
Continuing further, Amberen.com provides a long list of clinical studies on both Amberen and on its ingredients.
The most recent studies were conducted between 2005 and 2008.
The 2005 Study: In a clinical placebo-controlled study of Enerlit-Clima (a succinate-based food additive), researchers noted an increase in estradiol levels in women who received an Amberen-like compound. 
Unfortunately, the details of this study are limited. I don’t know if Enerlit-Clima produces the same results as Amberen, nor do I know additional factors that may have altered the results. Did the women change their diets or exercise patterns? Were there any additional side effects from the compound?
The 2007/2008 Study: This is the study mentioned briefly in my description of ammonium succinate. Researchers observed Amberen’s effects on mice for 4 weeks. The results: “Succinate-based therapy alleviated many biochemical symptoms of menopause in both aging mice and early menopausal women, as well as neurovegetative and psycho-emotional disorders.” 
While promising, consumers should note that the study was in mice, not humans. The ingredient used was a succinate-based composition and not necessarily Amberen.
I love that Amberen manufacturers provide plenty of research to back their formulas – most diet pills use unproven ingredients and don’t bother to explain what they’re for.
However, I’m still not entirely sold on Amberen based on these studies. Long term human trials on Amberen would be preferable to short-term animal studies.
What About Claims to Reduce Belly Fat?
Many consumers seek out Amberen due to widely broadcasted radio commercials. These commercials claim Amberen targets “stubborn belly fat.”
As mentioned earlier, Amberen is designed to treat menopausal symptoms, not fight fat. Though menopause may trigger unwanted weight gain and Amberen may stabilize hormones causing weight gain, fighting fat is not the number one goal with this product.
Furthermore, for this claim to be true, Amberen would have to be capable of spot reduction. As far as I can tell, there is no credible evidence to suggest this is possible. Amberen ingredients are not fat burners or appetite suppressants.
Are the Ingredients Safe?
I’m usually hesitant about proprietary blends because this implies the manufacturers have something to hide. After all, if the ingredients were in their correct amounts, wouldn’t manufacturers want to advertise it?
On the other hand, 400 mg of vitamins, minerals, and amino acids don’t particularly worry me. Amberen ingredients are safe and actually recommended by the FDA when used correctly.
From the Amberen reviews I’ve read, side effects are mild but individual results vary. Some consumers received the results they wanted without negative side effects, while others did not.
Lexlie at Amazon.com wrote, “I have only 5 days left on my 30 day pack, and the hot flashes have worsened, and I’ve gained 5 lbs. So I don’t like this product.”
How to Use Amberen
C Bismuth at Amazon.com explained in her review, “One direct criticism: it says 60 capsules on the label, but it is a 30 day supply. You must take 2 capsules each day, they are two different colors, but its unclear whether they are identical or different in composition.”
On the other hand, Amberen.com does give some additional advice: “Although weight loss was not clinically evaluated by test administrators during the Amberen clinical trials, some women report varying degrees of weight loss as a result of the hormonally balance obtained by with their use of Amberen’s recommended 90-day course. A healthy diet and proper exercise are always recommended for any weight loss efforts.”
Is Amberen Affordable?
Amberen.com offers two different packages:
30 Day Supply: This package costs $49.99 and is not backed by the 30 day guarantee.
90 Day Supply: This package costs $99.98 and is backed with a 30 day guarantee. It also includes a free 30 day supply, a weight loss guide, an Amberen diet menu, and professional consultation.
However, you can save a few extra dollars by ordering through other sellers:
• Amazon.com: $43.43
• Drugstore.com: $49.99
• eBay.com: $21.49
Is There a Guarantee?
The Amberen 30-day money-back guarantee only applies to the 90 day supply purchased at Amberen.com.
According to the terms and conditions, you can return your two unopened, shrink-wrapped packages within 30 days of your purchase date to receive a prompt refund. The first 30 day supply is yours to keep. It does not cover shipping and handling.
It may take up to 5 business days upon receiving the product before manufacturers will process the refund.
Who Makes Amberen?
Amberen is made by Lunada Biomedical, though it was originally developed by Eugene Maevsky, a prominent Russian physician and biochemist.
According to the Better Business Bureau, Lunada Biomedical received an A- score on an A to F rating scale. The company has been BBB accredited since 2008 and the only factor that lowered Lunada’s rating is the “length of time the business has been operating.”
The complaint history for the company demonstrated that Lunada Biomedical “gave proper consideration to complaints presented by the Bureau.”
This sounds fairly impressive at first, but there is one small mark on its record.
The National Advertising Division, an investigative unit of the BBB, asked Lunada Biomedical to modify or discontinue some of Amberen’s claims as a dietary supplement. The claims were exaggerated to the point of being fraudulent, having no proof Amberen could achieve such effects.
The challenged claims included “With Amberen you take just 2 capsules a day for 90 days. The capsules are very small and easy to swallow. Relief is fast and lasting. On average, you can expect the effects of Amberen to last for up to 3 months after you’ve completed your course.”
And “Amberen has the unique ability to rejuvenate your hypothalamus—the master gland that controls your body’s hormone production. This, in turn, promotes balanced production and circulation of hormones throughout your body, supporting the optimal function of your vital organs. Energy metabolism is soon restored. Suddenly you feel younger! And it’s completely natural; Amberen contains no artificial hormones or harmful ingredients, and is clinically proven to rejuvenate your natural neuroendocrine mechanisms. This means better hormonal balance. And better hormonal balance means less symptoms.”
Fortunately, Lunada Biomedical responded promptly to the NAD’s requests and “took necessary and appropriate steps in voluntarily discontinuing certain claims and testimonials.” 
One satisfied consumer at eBay.com wrote, “I’m now on day 8 of taking my first course of Amberen. I’m still getting hot flashes, however I don’t get as many, maybe 4 or 5 a day compared to 12 to 15. The intensity isn’t as bad either now and they are over much sooner. I feel much perkier in myself and have more energy. My sleep is getting better too, the other night had a whole 8 hours undisturbed sleep.”
While positive reviews such as these are encouraging if you’re looking for relief from hot flashes, I’ve found that Amberen’s effects on other menopausal symptoms are fairly limited. Many consumers complained that Amberen did not stimulate libido as advertised, while others mentioned that it did not result in weight loss.
While Amberen is a clinically studied and proven supplement for menopause, don’t expect it to be a mind-blowing diet pill. As with any hormone balancing pill (or diet pills in general), individual results will vary.
 Eugene Maevsky et al. “A succinate-based composition ‘rejuvenates’ ageing mice and alleviates menopausal symptoms in women without sex hormone replacement therapy.” Gerontology, Endocrinology. September 2007. Available from: http://www.medline.ru/public/pdf/8_046e.pdf
 “Monosodium L-Glutamate.” Database of Select Committee on GRAS Substances (SCOGS) Reviews. Available from: http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=217
 Peskov AB, et al. “Succinate-based preparation alleviates manifestations of climacteric syndrome in women.” Bulletin of Experimental Biology and Medicine. 2005 Sep;140(3):312-4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16307045
”NAD Asks Lunada to Discontinue Certain Amberen menopause Claims.” Nutraceuticalsworld.com. Available from: http://www.nutraceuticalsworld.com/contents/view_breaking-news/2012-06-06/nad-asks-lunada-to-discontinue-certain-amberen-menopause-claims/