Every website selling Cupuacu Pure features a clip from The Today Show discussing how cupuacu is the next amazing superfruit.
According to this clip and Cupuacu Pure advertising, cupuacu is so rich in antioxidants it benefits a myriad of health issues from weight loss to skin care. Even so, Cupuacu Pure is mostly said to enhance weight loss.
While superfruits like cupuacu are usually safe, they also often require more than antioxidants to produce true weight loss. Let’s take a closer look at Cupuacu Pure to determine its efficacy as a diet pill.
Who Makes It?
Cupuacu Pure’s website is copyrighted by Natural Nutrition. Unfortunately, Natural Nutrition doesn’t seem to have its own website. Consequently, the business practices of this company remain largely unknown.
What’s In It?
From the product website, it seems Cupuacu Pure contains only one ingredient: cupuacu. Cupuacu supposedly contains some of the strongest known antioxidants. Each antioxidant is said to have separate weight loss effects.
Quercetin is an antioxidant used for a variety of health issues, though it’s only strongly linked to reducing prostate inflammation and pain.  In one study, rats taking quercetin burned more fat, which boosted athletic performance. But, this study doesn’t discuss quercetin’s weight loss effects. 
Catechin is an antioxidant often credited with giving green tea its weight loss ability.  However, not all studies on green tea’s catechins resulted in weight loss.  Consequently, cupuacu’s catechins aren’t proven weight loss stimulators either.
Theograndins are a type of antioxidants found, so far, only in cupuacu. Currently, scientists have performed only limited studies on theograndins.  Hence, their effects on weight loss aren’t clear.
Cupuacu Pure’s website describes niacin as vitamins B1, B2, and B3. But, the term niacin usually identifies only vitamin B3. Vitamin B3 contributes to an efficient metabolism, which might aid weight loss. But, more recent research indicates too much niacin causes weight gain. 
Theacrine is a molecule similar to caffeine.  However, it hasn’t been intensely studied as a weight loss enhancer.
While some of these antioxidants are present in other diet ingredients, scientists haven’t definitively proven they cause weight loss.
As for cupuacu itself, scientific research of this alleged superfruit is also limited. Cupuacu weight loss studies are not prominently published or well publicized.
At best, I found several studies identifying cupuacu’s antioxidants.  But, these antioxidants aren’t proven to enhance weight loss. Hence, right now science doesn’t support using Cupuacu Pure as a potent diet pill.
What Do Customers Say?
CupuacuPure.com, the product’s official website, features testimonials from five female customers. As is customary with company-endorsed testimonials, these women had only positive things to say about Cupuacu Pure. Here’s a selection of their comments:
• Isabel: “Not only did I see a change on the scale, but I also saw a BIG change in my figure.”
• Becca: “It’s safe, natural, and it’s the only product that works for me.”
• Sharon: “I was able to lose the fat that no other diet program could remove.”
• Vanessa: “When I found Capuacu Pure, I knew this was the right product for me.”
• Kendra: “I lost more than I could imagine! That’s amazing!”
While these comments indicate Capuacu Pure greatly enhances weight loss, they aren’t specific. And, they aren’t a substitute for scientific testing. With consumer feedback alone, it’s impossible to determine if a diet pill’s results are typical, repeatable, or long-lasting.
How Many Pills Are in a Day’s Serving?
The Cupuacu Pure website is clear about when and how many of these diet pills to take per day. The recommended dose is one in the morning and one at night. Although it’s not stated explicitly, it’s implied each pill contains 250 mg cupuacu.
Unfortunately, the website doesn’t provide any further directions for taking Cupuacu Pure. For instance, there are no instructions about taking a dose with a water or food.
What Does It Cost?
Cupuacu Pure sells in three packages:
• 3 bottles for $37
• 6 bottles for $67
• 10 bottles for $97
A one-month supply uses 2 Cupuacu Pure bottles. Even in the smallest package, Cupuacu Pure is a pretty competitively priced diet pill.
Cupuacu Pure’s website also promises a no-hassle money-back guarantee policy. However, the website doesn’t have a terms and conditions page outlining more explicitly how to obtain a refund. And, the only hint at how to get a refund is the ordering phone number, 1-800-291-4798.
I normally appreciate when a company offers a money-back guarantee. But, too many questions about Cupuacu Pure’s return policy remain unanswered for my liking.
Is Cupuacu Pure a True Diet Pill?
Because of the limited research on cupuacu and weight loss, Cupuacu Pure is not yet proven as a diet pill.
Several Cupuacu Pure customers report losing weight with this diet pill. But, their words alone do not convince me cupuacu lives up to the superfruit title.
On the positive side, Cupuacu Pure is fairly inexpensive and probably doesn’t cause any side effects. Even so, I suggest waiting for better scientific evidence before using Cupuacu Pure as a diet pill.
 WebMD. “Quercetin.”
 Wu, J, W Gao, et al. “Quercetin alters energy metabolism in swimming mice.” Applied Physiology, Nutrition, and Metabolism. 37.5 (2012): 912-22.
 Nagao, Tomonori, Yumiko Komine, et al. “Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men.” American Journal of Clinical Nutrition. 81.1 (2005): 122-29.
 Hursel, R, W Viechtbauer, et al. “The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis.” Obesity Research. 12.7 (2011).
 Yang, H, P Protiva, et al. “New bioactive polyphenols from Theobroma grandiflorum (“cupuacu”).” Journal of Natural Products. 66.11 (2003): 1501-4.
 Duggett, Anna. “Niacin and Weight Loss.” Drugsdb.com. 2012 Jun 18.
 Feduccia, AA, Y Want, et al. “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.” Pharmacology, Biochemistry, and Behavior. 102.2 (2012): 241-8.
Ab Cuts CLAx
Supplement manufacturer Corr-Jensen made quite a success with its Ab Cuts line in recent years.
Ab Cuts products all use different formulas and take different tactics, but each falls under the umbrella of weight loss and muscle development. The latest Ab Cuts product, CLAx, purportedly continues that positive tradition.
According to advertisements, using Ab Cuts CLAx leads to:
• A modest reduction in body fat
• Better muscle tone
• A healthier body composition
• An overall better physique
I’m glad to see such moderate claims made on a weight loss supplement. Usually this isn’t the case. However, are these claims modest because the product is ineffective? To find out, I’ll investigate some pertinent points regarding Ab Cuts CLAx.
What Makes CLAx Different From Other Ab Cuts Products?
Nearly every Ab Cuts product relies on conjugated linoleic acid (CLA). However, in these products, CLA is usually paired alongside other ingredients to enhance effectiveness. Typically, these ingredients are stimulants or other herbal extracts with a somewhat stronger effect than CLA.
However, CLAx is essentially CLA flying solo. With no filler or supporting ingredients, CLAx is Corr-Jensen’s attempt to join the CLA supplement market. This supposedly makes CLAx a good choice for people who would like a little outside help in their weight loss efforts, but aren’t looking to invest in a complicated diet pill.
While I applaud Corr-Jensen’s efforts to achieve simplicity, these one-ingredient formulas usually seem silly to me. Why would a consumer choose to pay extra money for a designer label, when they can get the same thing at the local nutrition store for less money and hassle?
Perhaps Corr-Jensen makes up for the simple formula with other perks. Let’s continue our investigation of CLAx to find out.
What Does CLA Do for Fat Loss?
CLA is a unique weight loss supplement in that it burns fat without affecting the central nervous system. While other fat burners act as stimulants, CLA triggers fat loss by breaking down fat and preserving muscle.
By destroying fat cells before your body stores them, the lipoprotein lipase (LPL) enzyme in CLA prevents future weight gain. This process also increases the amount of fat burned as energy, encouraging breakdown and utilization of existing fat stores.
CLA also supports muscle development. Not only does this ensure dieting won’t lead to muscle breakdown, it improves body composition and quality. The more muscle you have, the better toned your body is. And because muscle also increases metabolic rate, weight loss potential increases.
However, CLA is not a miracle weight loss supplement. It is largely accepted as a weight loss aid, meaning it supports existing weight loss efforts but isn’t strong enough to induce weight loss on its own.
Are There Any CLA Studies?
Studies supporting CLA’s effectiveness as a weight loss aid are mixed. Though most studies find CLA supplementation improves weight loss efforts, results are modest and not always present.
The most promising, and most frequently-cited, study took place in 2000. Researchers split 180 overweight adults into 2 groups, and gave one group 3.4 g CLA daily and the other group an equal olive oil dosage as a placebo.
The subjects were monitored for a year. Some made rigorous changes to diet and exercise habits, while others only made modest improvements. At the end of the study, the CLA group showed a 7 to 9% reduction in body fat mass. Those who improved their diet and exercise lost even more body fat. Subjects in the placebo group showed no statistically significant changes .
This study speaks to CLA’s effectiveness, although the results were comparatively modest.
However, not all studies are as positive about CLA’s weight control benefits. In a 2006 study, researchers looked at CLA’s ability to prevent weight gain in formerly overweight or obese subjects. Because CLA purportedly changes fat breakdown and utilization, taking CLA should ostensibly prevent subjects from re-gaining weight.
Unfortunately, this didn’t happen. Despite taking 3.4 g CLA daily, subjects still gained between 8 and 10 pounds at the end of the year .
So, while study results are mixed, there is a general agreement in the scientific community that taking CLA along with a healthy diet and exercise program leads to moderate gains in weight loss.
Is the CLA in Ab Cuts CLAx of Good Quality?
Next we need to determine if the CLA in Ab Cuts CLAx is actually of good quality and included in the in the appropriate amounts.
It seems Corr-Jensen has done well on this point, because the company includes exactly 3.4 grams of CLA derived from safflower oil. Safflower oil is the premier CLA source, surpassing even sunflower oil in its potency.
Safflower oil is said to produce much more CLA than sunflower oil, and therefore gives you the most bang for your buck. Because sunflower oil is significantly less expensive than safflower oil, however, many companies continue to use sunflower oil.
It’s nice to see Corr-Jensen doesn’t take this shortcut, instead paying a little extra for the best quality CLA.
Is Ab Cuts CLAx Expensive?
Because Ab Cuts CLAx is brand new, its availability is fairly limited. Right now, CLAx sells for $24.98 per 120-serving bottle at the following locations:
This availability will likely expand as CLAx regains popularity. For now, however, these are your options.
And actually, this price isn’t a bad one. Though it’s a little more expensive than most CLA supplements, it has the advantage of being included in the exact dosage needed to work. It’s also a high-quality CLA source, and the product includes enough servings for 40 days of continual CLA supplementation.
Should You Take It or Leave It?
Ab Cuts CLAx is a decent product with a moderate price and a good CLA source. If you’re looking for a mild supplement to support weight loss efforts, Ab Cuts CLAx is the way to go.
However, if you want something more substantial, you’ll likely be disappointed by CLAx. In this case, it’s better to seek out products with a more traditional and diverse formula.
 Blankson, Henrietta, Jacob Stakkestad, Hans Fagertun, Erlin Thom, Jan Wadsetin, and Ola Gudmundsen. 2000. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of Nutrition: Vol. 143, Issue 2.
 Larsen, et al. 2006. Conjugated linoleic acid supplementation for one year does not prevent weight or body fat regain. American Society for Nutrition: Vol. 83, Issue 3.
Nutrition 53 Lean1
According to a reviewer from Amazon.com, the ingredient list for Nutrition 53 Lean 1 “reads like a fresh produce section at a market had a baby with a Centrum 1-a-day tablet.”
With over a dozen fruits and vegetables along with amino acids, vitamins, and weight loss aids in Nutrition 53 Lean 1’s supplement facts, this description isn’t too far off.
Will all the ingredients in Nutrition 53 Lean 1 really promote weight loss?
About Nutrition 53
According to Nutrition53.com, the company started when NFL player Bill Romanowski sought help to restore memory lost from concussions. A new formula was developed: Neuro1. Now Nutrition53 provides nutritional products that “deliver better health, greater confidence, and a brighter future.”
According to the Better Business Bureau, Nutrition 53 started in 2007, but there isn’t enough information to rate the business.
Nutrition 53 Lean1 Nutrition Facts
When determining the quality of a protein shake, it’s important to look at nutrition facts such as calories, protein, and sugar content.
Shakes with too many calories add significantly to your daily caloric intake, but shakes low in calories can be used to replace a meal and cut calories (and therefore promote weight loss). With 220 calories per serving, Nutrition 53 Lean1 has enough to trigger satiety, but is also a low enough amount to cut down caloric intake for a meal.
However, if you add Nutrition 53 Lean1 to your diet without cutting back on other food intake, it will simply add more calories and no weight loss benefits.
With 20 g protein, Nutrition 53 Lean1 has a solid amount of protein per serving (most quality shakes have between 10 and 30 g). This is enough promote satiety as well as provide the amino acids necessary for muscle growth.
Some diet shakes have too much sugar, which adds significantly to your daily sugar allotment and may even cause weight gain. With 11 g sugar, Nutrition 53 Lean1 isn’t exactly low in sugar. There are numerous shakes lower in sugar, but this doesn’t completely discount Lean1’s value if it can make up for it with other nutrients.
Nutrition 53 Lean1 Ingredients
Lean1 contains a slew of vitamins, including vitamin C, thiamin, niacin, magnesium, and zinc, all of which are found at a 50% daily value.
It also contains a protein blend, over a dozen fruits and vegetables, and other weight loss-promoting ingredients. Indeed, it doesn’t look like Lean1 has left anything out.
Let’s examine some of the key ingredients in Nutrition 53 Lean1.
N53 Protein Blend
Milk Protein Isolate. Milk protein isolate is a milk derivative, yet it does not contain milk. It’s easily digestible and is low in calories and sugar, making it an effective and desirable protein source. 
Whey Protein Isolate. Whey protein has been processed to remove fat and lactose. This optimizes total protein content, although other health-promoting components may be removed. Males who supplemented with a combination of whey protein and creatine increased lean tissue mass and bench press strength. 
Micellar Casein. Caseins are phosphoproteins found in milk that contain muscle-building amino acids. Micellar casein elevates amino acids in the bloodstream for up to seven hours after consumption, aiding muscle building and repair. 
Leucine. Leucine builds and repairs muscle tissue. In one study, leucine supplementation combined with resistance training prevented muscle damage and resulted in muscle gains. 
N53 Fruit and Vegetable Blend
Fibersol. Fibersol is patented maltodextrin, a digestive-resistant fiber proven to reduce hunger and aid weight loss. A study shows that overweight men lost an average of 19 pounds while following a reduced calorie, high fiber diet plan. 
Dehydrated Fruits and Veggies. Among the many fruits and veggies in the blend are dried or dehydrated carrot, watermelon, tomato, cabbage, and blueberry.
N53 Vitamin and Mineral Matrix
Hoodia Gordonii. Hoodia supposedly curbs appetite, and African bushmen even eat it to decrease hunger during hunts. However, additional scientific proof is needed to determine hoodia’s effect on weight loss. 
Green Coffee Bean Extract. Due to the hunger-reducing effects of chlorogenic acid, green coffee bean may cause weight loss. But, studies are still in the preliminary stages and should not be taken as fact. 
Acai Berry. Acai berry provides disease-fighting antioxidants and hunger-reducing monounsaturated fats. Overweight adults who took acai pulp twice daily for a month reduced cholesterol and fasting glucose. However, acai berry is not scientifically proven to aid weight loss.
Mix two to three scoops with eight to ten ounces cold water. Mix vigorously or use a shaker.
You should not take this product if you are pregnant or nursing. Talk to your doctor before using if you have any medical concerns.
Be aware Lean1 contains milk, soy, and wheat.
Nutrition 53 Lean 1 is available for the following prices:
• $39.97 at Nutrition53.com
• $21.78 to $47.99 at Amazon.com (depending on flavor)
• $32.98 at SupplementWarehouse.com (chocolate flavor)
• $33.84 at AllStarHealth.com (chocolate)
• $35.99 at VitaminShoppe.com (chocolate)
Nutrition 53 Lean1: The Bottom Line
Nutrition 53 Lean1 contains many important nutrients that should improve overall health. And, it’s low enough in calories to promote weight loss. As far as diet shakes go, I’d say it’s a pretty good pick. However, you may find a diet shake lower in sugar content and lower in price.
 Davita Parks. “What Is a Milk Protein Isolate?” 14 June 2011. Available from: http://www.livestrong.com/article/289039-what-is-a-milk-protein-isolate/
 Darren G. Burke et al. “The Effect of Whey Protein Supplementation With and Without Creatine Monohydrate Combined with Resistance Training on Lean Tissue Mass and Muscle Strength.” International Journal of Sport Nutrition and Exercise Metabolism. 2001; 11: 349-364. Available from: http://chua2.fiu.edu/faculty/kalmand/HUN6248/ppp/IJSNEM%20Whey%20with%20without%20creatine%20RT%20and%20LBM%20effects%20Burke%209-2001.pdf
 “Why is Micellar Casein Important?” IdahoMilkProducts.com. Available from: http://idahomilkproducts.com/content/why-micellar-casein-important
 S. Nissen et al. “Effect of leucine metabolite ?-hydroxy-?-methylbutyrate on muscle metabolism during resistance-exercise training.” Journal of Applied Physiology.1996; 81 (5): 2095-2104. Available from: http://jap.physiology.org/content/81/5/2095.short
 Olaf Mickelsen et al. “Effects of a high fiber bread diet on weight loss in college-age males.” American Journal of Clinical Nutrition. 1979; 32 (8): 1703-1709. Available from: http://agris.fao.org/agris-search/search/display.do?f=1981/US/US81050.xml;US7939818
 “Hoodia.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-1079-HOODIA.aspx?activeIngredientId=1079&activeIngredientName=HOODIA
 Joe A. Vinson et al. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.” Diabetes Metab Syndr Obes. 2012; 5: 21-27. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3267522/
 Jay K. Udani et al. “Effects of Acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: A pilot study.” Nutrition Journal. 2011; 10 (45). Available from: http://www.biomedcentral.com/content/pdf/1475-2891-10-45.pdf
Omega Sports BURN 24
“Insulin,” warns Omega Sports, “can shatter your efforts to lose weight and burn that unsightly body fat.”
To fight insulin’s effects, Omega Sports created BURN 24, an all-natural fat burner that supposedly inhibits fat storage and allows for better fat burning 24 hours a day.
To see if BURN 24 really stop the “perfect storm for weight gain”, I researched the ingredients behind the product.
What’s in BURN 24?
BURN 24 contains several ingredients intended to inhibit insulin activity and boost thermogenesis.
Green Coffee Bean Extract (250 mg) is clinically proven to promote weight loss. It contains chlorogenic acid which is the driving force behind its effectiveness. A 2007 clinical study shows chlorgenic acid reduces glucose absorption by 6.9%, resulting in significant weight loss.
Momordica Charantia Extract (200 mg), often known as bitter melon, lowers blood glucose levels in rats. This decrease appears to promote thermogenesis,resulting in fat burn.
It’s possible momordica charantia exhibits similar effects on humans but clinical studies have yet to be performed.
Berberine Hydrochloride (200 mg) is a botanical alkaloid proven to lower blood glucose in humans. It appears berberine achieves this effect by promoting glycolysis, the breaking down of glucose into three other chemicals.
Bergenin (150 mg) is not actively involved in fat burn, but it promotes weight loss by inhibiting insulin’s fat-building actions. Many researchers believe bergenin increases norepinephrine binding to fat cells, increasing fat burn.
Gymnema Sylvestre (150 mg) triggers insulin release to lower blood glucose. Gymnema sylvestre’s presence in BURN 24 is confusing because BURN 24 is marketed as an insulin inhibitor.
Cissus Quadrangularis (100 mg) lowers blood glucose levels by alleviating insulin resistance, allowing insulin to push more glucose out of the bloodstream into fat and muscle.
Like gymnema sylvestere, this ingredient’s inclusion is confusing as it facilitates insulin’s storage of glucose as fat cells, not fat burn.
Piper Nigrum (6 mg) is a proven bioavailability enhancer, facilitating absorption and utilization of BURN 24’s ingredients.
In all, BURN 24 provides some proven ingredients to inhibit insulin action. However, the inclusion of gymnema sylvestre and cissus quadrangularis may counteract any potential benefits These two ingredients promote insulin release and improve insulin effectiveness, actions directly in conflict with BURN 24’s intended use to inhibit insulin.
Are There Possible Side Effects?
For most people, BURN 24 will not likely cause serious side effects. However, people taking diabetic medication should avoid using BURN 24. Many ingredients interact negatively with medication and lower blood glucose levels to life-threatening levels.
How Do I Use It?
Burn 24 is best taken before meals. Take one serving (2 capsules) each meal of the day.
Do not take more than 6 capsules a day.
How Much Does BURN 24 Cost?
Burn 24 can be purchased online from various vendors. The best deals I found are from the following health supplement vendors:
• AllStarHealth.com: $39.99 plus $5.95 shipping for one 180-capsule bottle
• BestPriceNutrition.com: $39.99 plus $4.99 shipping for one bottle
• NutraPlanet.com: $39.99 plus $6.95 shipping for one bottle
Omega Sports offers a 100% money-back guarantee on all its products regardless of where you buy it.
While I like that Omega Sports provides dosage amounts for each of its ingredients, I don’t see BURN 24 as an effective weight loss supplement.
It appears some of the ingredients actually counteract the insulin-inhibiting effect of other ingredients. Furthermore, there are too few consumer reviews to verify its effectiveness.
Until better proof of the effectiveness of BURN 24’s formula is known, pass on this product.
 WebMD.com. “Green Coffee Beans May Aid Weight Loss.” Accessed 4.26.2013. http://www.webmd.com/diet/news/20120328/green-coffee-beans-may-aid-weight-loss
 Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research, 35.6 (2007): 900-908. http://imr.sagepub.com/content/35/6/900.short
 Nerurkar, Pratibha V., et al. “Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes.” BMC Complementary and Alternative Medicine,10.1 (2010): 34. http://www.biomedcentral.com/1472-6882/10/34
 Yin, Jun, et al. “Berberine improves glucose metabolism through induction of glycolysis.” American Journal of Physiology-Endocrinology And Metabolism, 294.1 (2008): E148-E156. http://ajpendo.physiology.org/content/294/1/E148.long
 See Nyasse, B., et al. “Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei.” Die Pharmazie-An International Journal of Pharmaceutical Sciences, 59.6 (2004): 492-494. Trypanocidal activity of bergenin
 Suite101.com. “Bergenin.” Accessed 4.30.2013. http://suite101.com/article/bergenin-a103299
 Persaud, S. J., et al. “Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability.” Journal of Endocrinology, 163.2 (1999): 207-212. http://www.ncbi.nlm.nih.gov/pubmed/10556769
 Chidambaram, Jaya, and Anuradha Carani Venkatraman. “< i> Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet.” Food and Chemical Toxicology, 48.8 (2010): 2021-2029. http://www.ncbi.nlm.nih.gov/pubmed/20450951
 Umesh, Patil, et al. Role of Piperine as a Bioavailability Enhancer.” International Journal of Recent Advances in Pharmaceutical Research, 10 (2011): 16-23. http://www.ijrapronline.com/issues3/UK_PATIL_IJRAPR_16-23.pdf
 OmegaSportsNutrition.com. “Do you offer a 100% money back guarantee?” Accessed 4.30.2013. Omega Sports Nutrition 100% Money Back Guarantee
“Synedrex is physician formulated for individuals who want to lose weight, drop body fat, and boost energy now!” That’s one bold claim posted on the official website.
With a claim like that, this one-dose daily thermogenic diet pill seems to guarantee quick and amazing results. Curious about Synedrex’s safety and effectiveness, I investigated further.
Ingredients in Synedrex
Synedrex’s ingredients are the most important indicator of its weight loss and energy boosting powers.
Methylxanthines are naturally occurring stimulants that increase energy and affect heart rate. Caffeine is the most well-known methylxanthine. 
Synephrine often goes by the name “bitter orange.” This stimulant is used to promote weight loss. But, bitter orange also causes dangerous cardiovascular reactions that likely nullify its benefits. 
Green Tea Extract
Green tea extract contains antioxidants known as catechins which may induce weight loss.  However, scientists still think further research about green tea is necessary. 
Sulbutiamine is a type of vitamin B1. Scientists have researched it as a treatment for chronic fatigue.  One study noted 600 mg a day is the minimum effective dose. 
One source credits R-B-methylphenylehtylamine with giving energy, suppressing appetite, and burning fat.  Available research fails to confirm these effects. 
1,3 dimethylamylamine, more commonly known as DMAA, is an artificial stimulant that speeds up metabolism and encourages fat burning. However, DMAA causes side effects such as increased heart rate, higher blood pressure, heart attack, or stroke. 
Yohimbine is a chemical found in the plant yohimbe. Researchers behind a 1991 study found yohimbine caused more weight loss than placebo, but not by much. 
Alpha-lipoic acid, also known as ALA, is found in every cell of the body because of its role in energy production. Several studies show ALA promotes weight loss. 
Sandalwood oil is a traditional remedy for infections, colds, and heart and gallbladder problems.  I couldn’t find any research linking it with energy or weight loss.
This jojoba extract might suppress appetite.  But, science so far hasn’t confirmed this effect.
Synedrex’s proprietary blend features a mixed-bag of weight loss ingredients. Some demonstrate great efficacy but come with safety concerns. And, others have very little research backing them as diet pill ingredients. Overall, I’m not impressed.
Potential Side Effects of Synedrex
Several Synedrex ingredients come with serious safety concerns. For instance, Consumer Reports recommends avoiding stimulants synephrine and yohimbine because they might increase risk of or even cause heart problems. 
Similarly, the FDA issued a warning about DMAA following reports of 42 heart related issues in people using DMAA products.  Even natural sandalwood oil might cause kidney damage if used for six weeks or longer. 
Those potential side effects raise serious concerns about Synedrex’s safety.
Customer Feedback on Synedrex
Unfortunately, Synedrex’s consumer reviews do little to alleviate the concerns about this diet pill’s safety. Although many people note Synedrex helped them lose weight, most reviewers also note powerful side effects.
Nausea, headaches, and sleeplessness are among the most commonly reported side effects of taking Synedrex. In fact, many people noted extreme nausea that lasted hours and often led to vomiting. Even worse, many people credited this nausea with entirely suppressing their appetite. That’s not exactly the safest method for decreasing hunger.
Of course, not all Synedrex users experienced this intense nausea. However, many who didn’t noted an appetite suppression so strong they needed to force themselves to eat. Again, Synedrex seems effective, but perhaps dangerously so.
Other consumer-reported side effects of Synedrex include:
• Mood swings
• Muscle spasms
• Unquenchable thirst
• Increased heart rate
I found Synedrex for sale at the following websites:
• MetabolicNutrition.com: $59.99
• PlanetaryNutrition.com: $44.95
• Amazon.com: $39.75
Metabolic Nutrition offers a 30-day money-back guarantee on any purchases as long as the unused product is returned within those 30 days. However, I noticed that sometimes this site doesn’t have Synedrex in stock.
Synedrex contains such potent ingredients that one dose a day purportedly lasts 12 or more hours. People who have used Synedrex recommend taking the capsule early in the day just after eating breakfast. Following these directions might decrease nausea or late-night restlessness.
Summary of Synedrex
Synedrex might advertise a physician-approved formula, but it doesn’t earn my approval. Potentially dangerous ingredients and numerous reported side effects mean Synedrex fails to meet my diet pill standards. I recommend using a different diet pill than Synedrex.
 WiseGeek. “What Are Methylxanthines?” Available from: http://www.wisegeek.org/what-are-methylxanthines.htm
 Human Performance Resource Center. “HPRC Dietary Supplements Classification System: Bitter Orange (Synephrine).” Available from: http://hprc-online.org/dietary-supplements/files/Monograph_Synephrine.pdf
 Warner J. “Green Tea Fights Fat.” WebMD. 2006 Jan 26. Available from: http://www.webmd.com/diet/news/20050126/green-tea-fights-fat
 Cabrera C, Artacho R, Gimenez R. “Beneficial effects of green tea—a review.” J Am Coll Nutr. 206 Apr. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16582024
 Examine.com. “Sulbutiamine.” 2012 Oct 29. Available from: http://examine.com/supplements/Sulbutiamine/
 Tiev KP, Cabane J, Imbert JC. “[Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo].” Rev Med Interne. 1999 Oct. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10573727
 “Fastin/Phenethylamine – Weight Loss Support, Positive Moods & Energy Enhancer – Ingredients/Dose.” SmartBodyz.com. Available from: http://www.smartbodyz.com/Fastin-Phenethylamine-Side-Effects-Ingredients.htm
 ChemSpider. “?-Methylphenylethylamine.” Available from: http://www.chemspider.com/Chemical-Structure.1554538.html
 WebMD. “Dimethylamylamine.” Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-1258-DIMETHYLAMYLAMINE.aspx?activeIngredientId=1258&activeIngredientName=DIMETHYLAMYLAMINE
 Kucio C, Jonderko K, Piskorska D. “Does yohimbine act as a slimming drug?” Isr J Med Sci. 1991 Oct. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1955308
 Parepalo M. “Can You Lose Weight with Alpha Lipoic Acid?” Livestrong. 2011 Jun 14. Available from: http://www.livestrong.com/article/424901-can-you-lose-weight-with-alpha-lipoic-acid/
 WebMD. “White Sandalwood.” Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-116-Sandalwood++WHITE+SANDALWOOD.aspx?activeIngredientId=116&activeIngredientName=Sandalwood++(WHITE+SANDALWOOD)&source=2
 USDA Agricultural Research Service. “Simmondsin From Jojoba Checked for Appetite Suppression.” 2002 Jan 7. Available from: http://www.ars.usda.gov/is/ar/archive/dec00/jojoba1200.htm
 Consumer Reports. “Dangerous supplements: What you don’t know about these 12 ingredients could hurt you.” 2010 Sep. Available from: http://www.consumerreports.org/cro/2012/05/dangerous-supplements/index.htm
 FDA. “FDA challenges marketing of DMAA products for lack of safety evidence.” 2012 Apr 27. Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm302133.htm
 WebMD. “White Sandalwood.” Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-116-Sandalwood++WHITE+SANDALWOOD.aspx?activeIngredientId=116&activeIngredientName=Sandalwood++(WHITE+SANDALWOOD)&source=2
“Support Your Beauty from the Inside Out!”
Created by BeautyFit, BeautyCleanse is advertised as a gentle, all-natural laxative that supports “the body’s seven channels of elimination.” These channels include liver, lungs, lymphatic system, blood, colon, skin, and kidneys.
“BeautyCleanse is a comprehensive approach to internal cleansing,” explain advertisers. “BeautyCleanse combines 32 ingredients, including 21 natural herbs such as milk thistle, parsley, and dandelion leaf, that work to stimulate liver cleansing, increased blood flow to the kidneys, and elimination through the intestinal tract.”
While BeautyCleanse is designed primarily as a cleanser, I’m curious to see if this supplement is strong enough to promote weight loss as well.
What’s Inside the Bottle?
32 ingredients are pretty impressive, to say the least. I rarely see a supplement that contains so many all-natural herbs and botanicals.
However, reliable supplements are not based on quantity, but quality.
839 mg per serving divided among 32 ingredients severely limits an ingredient’s effectiveness. Although some ingredients undoubtedly have higher concentrations than others, the average ingredient concentration is less than 30 mg. Some ingredients need at least 2 or 3 times that amount in order to be effective.
Proprietary Herbal Detox Blend
Spirulina. Spirulina is a blue-green algae purported to reduce swelling and boost immunity. However, there is not enough clinical research on human subjects to verify its usage.
Parsley. Parsley is an herb commonly used to treat urinary tract infections and kidney stones. It contains the antioxidant quercetin, which protects against oxidative stress and even lowers cholesterol. 
Oat Straw. Oat reduces inflammation, lowers blood pressure, and improves circulation. For this reason, oat straw is commonly used to improve sexual performance. However, there is not enough evidence to confirm these effects.
Artichoke. Artichoke stimulates bile flow in the liver. This improves digestion and reduces nausea, vomiting, and gas. When combined with kidney bean extract, artichoke may reduce hunger and promote weight loss. 
But, BeautyCleanse does not contain white kidney bean extract. And, this study featured at least 200 mg standardized artichoke while BeautyCleanse features a fraction of this amount.
Fenugreek. Fenugreek contains phytochemicals which mimic estrogen. Consequently, it is commonly used to treat hormonal and reproductive disorders. Additionally, fenugreek studies suggest it blocks aromatase enzymes, minimizing testosterone to estrogen conversion. However, there is not enough research linking fenugreek to weight loss or to detoxification.
Dandelion Leaf. Also known as taraxacum, dandelion is a laxative and diuretic. It is an effective treatment for excess water retention, but it is not linked to fat burning or weight loss. 
Turmeric. Turmeric is traditionally used as an antiseptic and anti-inflammatory. Experts at Medline Plus state turmeric is possibly effective for treating upset stomach and reducing pain. 
Milk Thistle. Milk thistle contains flavonoids which protect the liver from environmental toxins. It reduces inflammation and encourages liver repair. 
Marshmallow Root. Used for over 2,000 years as a traditional inflammation treatment, marshmallow root contains a gummy substance called mucilage. When mucilage is mixed with water, it forms a gel that coats the throat and stomach to sooth irritation.
Experts found marshmallow root is effective for treating stomach ulcers and indigestion, but it is not linked to weight loss. 
Garlic. According to studies, garlic exhibits hypolipidemic, antiplatelet, and procirculatory effects, which means it’s an effective cholesterol treatment. 
Green Tea Extract. Green tea is naturally rich in antioxidants known as catechins. Not only do these catechins eliminate harmful toxins but they reduce body fat and lower cholesterol as well. 
Proprietary Neutraceutical Blend
L-Glutamine. Considered a major fuel source for cells, glutamine is the most abundant amino acid in the body. It promotes protein synthesis and muscle growth while improving gastrointestinal function. 
L-Glutathione. Glutathione is involved in tissue building and repair. Studies show glutathione is a defensive reagent against toxic xenobiotics (drugs, pollutants, carcinogens). 
Lycopene. Lycopene is a potent antioxidant. It protects against damage on a cellular level and is commonly used to prevent heart disease and atherosclerosis (hardening of the arteries). Experts believe lycopene may delay or prevent prostate cancer progression, but further research is needed. 
Quercetin. As mentioned above, quercetin is a potent antioxidant. It is clinically proven to lower cholesterol levels. 
Gamma Oryzanol. Extracted from rice bran oil, gamma oryzanol is popularly used to lower cholesterol and increase testosterone. While cholesterol research on gamma is promising, there is not enough evidence validating its use for testosterone.
Calcium D-Glutarate. Essential for strong bones and teeth, calcium is attracting attention in the medical community due to its potential effects on weight loss. Studies show calcium-rich diets may play a substantial role in reducing obesity and insulin resistance. 
Resveratrol. Resveratrol is a potent antioxidant which eliminates harmful free radicals. Some researchers believe resveratrol mimics dieting and exercise’s metabolic effects.  However, further research is needed to confirm these results.
Methyl Sulfonyl Methane. Often abbreviated to MSM, this bioavailable sulfur form is traditionally used as a pain reliever and anti-inflammatory ingredient. Some experts recommend MSM for osteoarthritis, but there is not enough information linking MSM to weight loss. 
N-Acetyl-L-Cysteine. A derivative of the amino acid cysteine, this compound binds to poisonous acetaminophen forms located in the liver. It eliminates harmful toxins and may play a role in preventing cancer. 
Zeaxanthin. Also known as lutein, this carotenoid vitamin is thought to filter light and protect eyes from sunlight damage. Experts recommend 6 mg lutein per day to prevent macular degeneration.  Though helpful, zeaxanthin is not proven to cleanse the body or promote weight loss.
Ginger. Ginger is popularly used as a digestive aid because it eases nausea and upset stomach. Researchers found ginger also increases thermogenesis and suppresses appetite, but even the researchers agree, “Additional studies are needed to confirm these findings.” 
Cayenne. Cayenne pepper contains the chemical known as capsaicin. This thermogenic ingredient temporarily increases internal temperature to promote calorie burning. Preliminary research suggests cayenne curbs appetite as well, but further studies are needed. 
Peppermint. Peppermint is a flavorful herb commonly used to treat digestive problems such as intestinal gas. It reduces muscle spasms and improves bile flow.
Spearmint. Like peppermint, spearmint is used to treat digestive disorders such as gas, indigestion, and nausea. Unfortunately, clinical research is limited.
Gentian. Gentian is traditionally used to prevent muscle spasms and treat parasitic worms. However, some studies suggest gentian contains carcinogens which increase the risk of developing benign and malignant tumors. 
Coriander. Coriander is popularly used to lower blood sugar and kill parasites, but there is not enough information to confirm these effects.
Fennel. In vitro studies suggest fennel contains antioxidants which reduce free radical damage. 
Papaya. Papaya contains the chemical papain which breaks down proteins, carbohydrates, and fats. It also contains the chemical carpain which is said to kill certain parasites. However, it should be taken with caution as it is known to damage the esophagus. 
Cumin. Cumin stimulates digestive enzyme secretion in the stomach. This in turn improves digestion and decreases intestinal gas. 
Black Pepper. Black pepper contains the chemical piperine which increases nutrient absorption. Although it has no direct effect on weight loss or cleansing, black pepper may increase BeautyCleanse’s effectiveness.
That’s quite the list! I’m impressed BeautyFit managed to cram so much into BeautyCleanse. Unfortunately, closer investigation reveals many ingredients are not clinically proven to promote weight loss or effectively eliminate toxins.
Are There Any Risks?
There are always risks when it comes to proprietary blends such as BeautyCleanse. Because ingredient concentrations are not provided, it is impossible to determine if the formula is safe or effective. Too much of an ingredient may cause side effects while too little won’t produce results at all.
Due to the sheer number of ingredients in BeautyCleanse, I assume most ingredients fall under the second category. Consequently, side effect risk should be minimal.
However, this doesn’t mean BeautyCleanse is side effect free.
Some ingredients are known to cause nausea, diarrhea, constipation, and gastrointestinal upset. Consequently, products containing these ingredients should only be used for a few days at most. BeautyCleanse is designed to be taken for 30 days at a time, which increases side effect risk.
If you are taking medication or have a medical condition, consult your doctor prior to using BeautyCleanse to ensure a safe experience.
Is BeautyCleanse Easy to Use?
BeautyCleanse’s greatest attribute is convenience. Simply take 2 capsules daily with food. That’s it! No strict schedules. No extreme exercise programs.
However, best results only come from following a healthy diet and regular exercise. BeautyCleanse is designed primarily for cleansing the body, but it’s up to you to ensure your diet stays clean.
Is BeautyCleanse Affordable?
BeautyCleanse is available from online distributors for the following prices:
• Bodybuilding.com: $31.65
• Amazon.com: $35.74
• BeautyFit.com: $26.99
Each bottle contains 90 capsules and, when used as recommended, should last approximately 45 days. This isn’t a bad deal.
Free samples are also available if you fill out a form provided at BeautyFit.com.
Is There a Money-Back Guarantee?
BeautyFit.com offers a 30 day guarantee on all their products. So, if you are not satisfied, return the remaining unused product for a full refund, less shipping and handling.
If you have any questions, call 954-530-6723 to reach customer service.
Is BeautyCleanse Worth a Try?
BeautyCleanse offers an impressive and comprehensive herbal blend. Many ingredients are clinically proven to eliminate harmful toxins and improve overall health.
However, some ingredients lack the research necessary to validate their use. Furthermore, some ingredients are known to cause negative side effects.
For the price, BeautyCleanse seems worth a try. For the risk, however, I wouldn’t recommend it.
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 Rondanelli, M., Giacosa, A., Orsini, F., Opizzi, A. and Villani, S. (2011), Appetite Control and Glycaemia Reduction in Overweight Subjects treated with a Combination of Two Highly Standardized Extracts from Phaseolus vulgaris and Cynara scolymus. Phytother. Res., 25: 1275–1282. doi: 10.1002/ptr.3425. Available from: http://onlinelibrary.wiley.com/doi/10.1002/ptr.3425/abstract
 Wilborn C, Taylor L, Poole C, Foster C, Willoughby D, Kreider R. “Effects of a purported aromatase and 5?-reductase inhibitor on hormone profiles in college-age men.” Int J Sport Nutr Exerc Metab. 2010 Dec;20(6):457-65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21116018
 “Dandelion.” University of Maryland Medical Center. Available from: http://www.umm.edu/altmed/articles/dandelion-000236.htm
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 “Milk Thistle.” University of Maryland Medical Center. Available from: http://www.umm.edu/altmed/articles/milk-thistle-000266.htm
 “Marshmallow.” University of Maryland Medical Center. Available from: http://www.umm.edu/altmed/articles/marshmallow-000265.htm
 Harunobu Amagase. “Clarifying the Real Bioactive Constituents of Garlic.” J. Nutr. March 2006 vol. 136 no. 3 716S-725S. Available from: http://jn.nutrition.org/content/136/3/716S.short
 Nagao T, Hase T, Tokimitsu I. “A green tea extract high in catechins reduces body fat and cardiovascular risks in humans.” Obesity (Silver Spring). 2007 Jun;15(6):1473-83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17557985
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 Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. “The changing faces of glutathione, a cellular protagonist.” Biochem Pharmacol. 2003 Oct 15;66(8):1499-503. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14555227
 “Lycopene.” Medline Plus. Available from: http://www.nlm.nih.gov/medlineplus/druginfo/natural/554.html
 Bok SH, Park SY, Park YB, Lee MK, Jeon SM, Jeong TS, Choi MS. “Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats.” Int J Vitam Nutr Res. 2002 May;72(3):161-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12098884
 “Gamma Oryzanol.” Examine.com. Available from: http://examine.com/supplements/Gamma+Oryzanol/
 Teegarden, Dorothy. “Calcium Intake and Reduction in Weight or Fat Mass.” J. Nutr. January 1, 2003 vol. 133 no. 1 249S-251S Available from: http://jn.nutrition.org/content/133/1/249S.short
 Moisse, Katie. “Red Wine Ingredient Resveratrol Mimics Diet, Exercise in Obese Men.” ABC News. Nov 1, 2011. Available from: http://abcnews.go.com/Health/w_DietAndFitnessNews/red-wine-ingredient-resveratrol-mimics-calorie-restriction-obese/story?id=14852698#.UW2ONhxJObM
 “MSM (Methylsulfonylmethane).” WebMD. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-522-MSM%20(METHYLSULFONYLMETHANE).aspx?activeIngredientId=522&activeIngredientName=MSM%20(METHYLSULFONYLMETHANE)
 “N-Acetyl Cysteine.” WebMD. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-1018-N-ACETYL%20CYSTEINE.aspx?activeIngredientId=1018&activeIngredientName=N-ACETYL%20CYSTEINE
”Lutein.” WebMD. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-754-LUTEIN.aspx?activeIngredientId=754&activeIngredientName=LUTEIN
 Mansour MS, Ni YM, Roberts AL, Kelleman M, Roychoudhury A, St-Onge MP. “Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study.” Metabolism. 2012 Oct;61(10):1347-52. doi: 10.1016/j.metabol.2012.03.016. Epub 2012 Apr 24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22538118
 Goodman, Brenda. “Study Suggests Pepper May Help Weight Loss When Combined with Other Weight Loss Efforts.” WebMD Health news. April 27, 2010. Available from: http://www.webmd.com/diet/news/20110427/cayenne-pepper-may-burn-calories-curb-appetite
 “Peppermint.” University of Maryland Medical Center. Available from: http://www.umm.edu/altmed/articles/peppermint-000269.htm
 Neil A. Littlefield, Boon-Nam Blackwell, Cynthia C. Hewitt, David W. Gaylor. “Chronic toxicity and carcinogenicity studies of gentian violet in mice.” Fundamental and Applied Toxicology, Volume 5, Issue 5, October 1985, Pages 902–912. http://dx.doi.org/10.1016/0272-0590(85)90172-1. Available from: http://www.sciencedirect.com/science/article/pii/0272059085901721
 Münir Oktay, ?lhami Gülçin, Ö.?rfan Küfrevio?lu. “Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts.” LWT – Food Science and Technology, Volume 36, Issue 2, March 2003, Pages 263–271. http://dx.doi.org/10.1016/S0023-6438(02)00226-8. Available from: http://www.sciencedirect.com/science/article/pii/S0023643802002268
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 Platel K, Srinivasan K. “Digestive stimulant action of spices: a myth or reality?” Indian J Med Res. 2004 May;119(5):167-79. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15218978
iSatori Garcinia Trim
Following earlier successes with top-selling diet supplements such as Razberri Ketone-Slim and Belly Off, iSatori recently announced its latest fat burner: Garcinia Trim.
As its name implies, Garcinia Trim features garcinia cambogia as its key ingredient.
According to Stephen Adele, Founder and CEO at iSatori, “a popular television medical show recently called Garcinia a standout diet aid. . .new research suggests Garcinia cambogia could be the ingredient that lets dieters lose weight without any special diet or exercise.” 
With so much media attention, it’s no wonder dieters are flocking to their nearest supplement retailer to see if the product will be the key to their success. Yet despite the hype, I remain skeptical.
Is Garcinia Trim the best choice?
A Quick Peek at the Formula
Not much is known about Garcinia Trim. Although the product is set to be released in May, the ingredient label and clinical information are not provided on the official website.
Unfortunately, the only facts I have (at the moment) are those provided by third-party press releases.
Still, I’m determined to give you the latest information on the most popular products, so here’s what I’ve learned so far.
As mentioned above, Garcinia Trim’s main ingredient is garcinia cambogia, an exotic fruit native to South India. Garcinia cambogia is touted to increase serotonin, inhibit lipolysis (fat synthesis), control appetite, reduce BMI, and maintain healthy cholesterol levels.
Assuming all these claims are true, then garcinia cambogia may be just what you need to slim down.
Unfortunately, garcinia cambogia studies are fairly mixed.
For example, in 1998, researchers tested garcinia cambogia’s effects on body weight and fat loss in human subjects. After 12 weeks, garcinia cambogia failed to produce significant weight loss results beyond that observed by a placebo. 
However, in 1999, garcinia cambogia experts wrote a follow-up to the same study. They explained that HCA, garcinia’s key component, is clinically proven to “suppress fatty acid synthesis, increase hepatic glycogen synthesis, suppress food intake, increase energy expenditure, curb appetite, reduce plasmatic cholesterol levels, and inhibit fat synthesis.” 
In a separate study, researchers found garcinia cambogia reduced insulin and leptin levels and efficiently improved glucose metabolism.  In another study, the flavonoids in garcinia cambogia successfully lowered lipid levels. 
While both of these studies are promising, they were conducted on animals, not humans. This makes me wonder if garcinia cambogia produces the same results in human trials or if the research was overhyped.
Potential Side Effects
Garcinia cambogia has not been tested for long-term use. Consequently, dieters are encouraged to use garcinia cambogia for less than 12 weeks at a time.
WebMD experts found garcinia causes nausea, digestive tract discomfort, and headache.
Is iSatori Reliable?
According to the official website, satori is a Japanese word which means “an epiphany or an awakening.” The “I” was added to make it more personal, and “so the name iSatori was born.”
iSatori was originally founded in 2001 by Stephen Adele alongside “top medical doctors and nutritional biochemists.” Since its founding, the company has grown dramatically, providing health supplements to thousands of retailers worldwide.
According to the Better Business Bureau, iSatori received an A+ rating on a scale of A+ to F. This is because of the low complaint volume filed against the company as well as the length of time the business has been operating.
Based on the BBB’s rating, I’d assume iSatori is fairly reliable.
Don’t Miss Out on the Latest Updates
For now, this is all I know about iSatori Garcinia Trim.
However, I’m keeping a close watch on iSatori Garcinia Trim. As soon as new information is available, I’ll do the best I can to keep you in the loop and give unbiased information on this promising new product.
Check back often so you don’t miss the latest updates on Garcinia Trim!
 “iSatori to Launch New Garcinia Trim™ Weight-Loss Supplement to Retail Stores Nationwide.” MarketWire. April 10, 2013. Available from: http://www.marketwire.com/press-release/isatori-launch-new-garcinia-trim-weight-loss-supplement-retail-stores-nationwide-otcqb-ifit-1777321.htm
 Steven B. Heymsfield, MD; David B. Allison, PhD; Joseph R. Vasselli, PhD; Angelo Pietrobelli, MD; Debra Greenfield, MS, RD; Christopher Nunez, Med. “Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent.” JAMA. 1998;280(18):1596-1600. doi:10.1001/jama.280.18.1596. Available from: http://jama.jamanetwork.com/article.aspx?articleid=188147
 Fabio Firenzuoli, MD; Luigi Gori, MD. “Garcinia Cambogia for Weight Loss.” JAMA. 1999;282(3):233-235. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-3-jac90006. Available from: http://jama.jamanetwork.com/article.aspx?articleid=1030241
 K Hayamizu, H Hirakawa, D Oikawa, T Nakanishi, T Takagi, T Tachibana, M Furuse. “Effect of Garcinia cambogia extract on serum leptin and insulin in mice.” Fitoterapia, Volume 74, Issue 3, April 2003, Pages 267–273. http://dx.doi.org/10.1016/S0367-326X(03)00036-4. Available from: http://www.sciencedirect.com/science/article/pii/S0367326X03000364
 Asha Sarah Koshy, L Anila, N.R Vijayalakshmi. “Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats.” Food Chemistry, Volume 72, Issue 3, February 2001, Pages 289–294. http://dx.doi.org/10.1016/S0308-8146(00)00225-9
 “Garcinia.” WebMD. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-818-GARCINIA.aspx?activeIngredientId=818&activeIngredientName=GARCINIA
GNC Total Lean CLA PM
GNC says Total Lean CLA maintains lean muscle mass and supports metabolism. Now, GNC Total Lean CLA PM supposedly adds stimulant-free support for a better night’s sleep.
Sleep and weight loss go hand in hand. Sleep loss may cause you to eat unhealthy food for quick energy, resulting in weight gain. So, if you’re struggling with weight loss and difficulty sleeping, GNC Total Lean CLA PM could be the diet pill for you.
But does this supplement actually do the difficult task of supporting both weight loss and sleep?
What’s in GNC Total Lean CLA PM?
GNC Total Lean CLA PM is made of ingredients that either promote weight loss or sleep.
CLA (3.40 g). CLA is the key weight loss ingredient in CLA PM. In one study, CLA lowered BMI and total adipose mass (abdominal fat) without altering lean mass.  Results such as this encourage supplement companies to claim CLA reduces belly fat, but results may vary.
CLA is also touted to have additional benefits, such as increasing metabolic rate and lowering insulin resistance.  Many studies agree CLA could be beneficial to weight loss and glycemic control.
Rest and Relaxation Complex
Valerian Root Extract (100 mg). Valerian benefits sleep structure and sleep perception. For those with mild insomnia, Valerian is a good alternative to heavy sleep aids. However, it may cause stomach upset, headache, or morning grogginess.
Its effects become stronger over time, so valerian results are best after a short time period rather than after the first use. 
L-Theanine (50 mg). Theanine is an amino acid found in green tea. In one clinical trial, boys with ADHD who consumed l-theanine had higher sleep percentage and efficiency scores.  But a theanine study on rats found there were no statistically significant effects on body weight. 
Lemon Balm Leaves Extract (50 mg). According to WebMD.com, lemon balm contains chemicals that exert a calming effect. In one study, a valerian/lemon balm combination promoted better sleep quality and was well tolerated by subjects.  Fortunately, lemon balm is likely safe to take short-term.
Hops Flower Herb Powder (50 mg). Together with valerian, hops reduced sleep latency in insomnia patients.  Interestingly, the same results were not seen with valerian alone, indicating the hops/valerian combination can be beneficial for sleep.
Passion Flower Herb Powder (50 mg). Passion flower improved sleep quality in forty-one subjects.  However, the study only lasted one week, so passion flower’s effect on sleep still lacks significant scientific evidence.
Restore and Recover Complex
Gelatin (50 mg). A protein made from animal products, gelatin strengthens bones and joints. Its effect on weight loss is not yet fully determined, although it did promote satiety, and thus reduce food intake, as part of a controlled study. 
Alpha Lipoic Acid (10 mg). Alpha lipoic acid exerts anti-oxidant and anti-inflammatory effects, which could indirectly assist weight loss. In one study, rabbits were fed high-cholesterol chow for 6 weeks. When alpha lipoic acid was added to their diets, they lost weight. 
L-Methionine (10 mg). This amino acid supplies sulfur and methyl, which is used to transform food into energy. Methionine also changes fat-soluble toxins into water-soluble waste. 
Silica (4 mg). Silica is added to supplements in order to promote powder flow. Long-term silica supplementation could destroy vitamin B1. Vitamin B1 deficiency leads to loss of muscle control and paralysis. 
Horsetail Rush Stems Extract (3 mg). Horsetail contains silica, which adds to potential side effects. Horsetail extract is also used as a diuretic, but this eliminates water weight instead of fat. 
Boron (2 mg). Boron generally doesn’t live up to its claims. In one study, it did not increase testosterone, lean body mass, or strength. 
Lutein (950 mcg). An important part of the diet, lutein is found in fruits and vegetables and promotes eye health. Many multivitamins include lutein.
Is GNC Total Lean CLA PM Safe to Take?
CLA PM may be safe to take for a short time, but most ingredients are not proven to be safe long term. In particular, long term silica use could lead to serious problems, such as loss of muscle control. Other CLA PM side effects include stomach upset, headache, and grogginess.
The label instructs you to take four softgels each night before bed. But, I suggest starting out with a smaller dose and assessing tolerance before taking the full dosage.
Do People Like CLA PM?
This is a hard question to answer, as reviews on this new product are scarce. Total Lean CLA (the daytime version) has received mixed reviews. 90% of users on GNC.com would recommend it to a friend, but results may be skewed as this is a product promoted by GNC.
How Much Does CLA PM Cost?
CLA PM is $39.99 at GNC.com and $31.95 at Amazon.com. This is a reasonable price for a supplement that will last for a month.
Should I Buy GNC Total Lean CLA PM?
GNC Total Lean CLA PM is a new product that has yet to prove its effectiveness and safety. I would choose a different diet pill that’s clinically-shown to work over time.
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 U. Koetter et al. “A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder.” Phytotherapy Research. 2007; 21 (9): 847-851. Available from: http://onlinelibrary.wiley.com/doi/10.1002/ptr.2167/abstract
 A. Ngan; R. Conduit. “A Double-blind, Placebo-Controlled Investigation of the Effects of Passiflora incarnate (Passionflower) Herbal Tea on Subjective Sleep Quality.” Phytotherapy Research. 2011; 25 (8): 1153-1159. Available from: http://onlinelibrary.wiley.com/doi/10.1002/ptr.3400/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false
 Veldhorst MA. “A breakfast with alpha-lactalbumin, gelatin, or gelatin + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP.” Clin Nutr. 2009; 28 (2): 147-55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19185957
 Zhekang Ying et al. “Lipoic acid effects on established atherosclerosis.” Life Sci. 2010; 86 (3-4): 95-102. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075920/
 Phoebe Strauss. “What is Methionine Good for?” LiveStrong.com. 2011. Available from: http://www.livestrong.com/article/533376-what-is-methionine-good-for/
 Elizabeth Thatcher. “Side Effects of Silica Supplements.” LiveStrong.com. 2011. Available from: http://www.livestrong.com/article/288425-side-effects-of-silica-supplements/
 Sarah Terry. “What is Horsetail Extract Good For?” LiveStrong.com. 2011. Available from: http://www.livestrong.com/article/152499-what-is-horsetail-extract-good-for/
 Ferrando AA; Green NR. “The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders.” Int J Sport Nutr. 1993; 3 (2): 140-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8508192
 “Lutein.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-754-LUTEIN.aspx?activeIngredientId=754&activeIngredientName=LUTEIN
MusclePharm Carnitine Core
“Carnitine Core utilizes the naturally-occurring amino acid L-carnitine to ramp up your metabolism, turning your body into a fat-burning machine.” So states the official website of MusclePharm Carnitine Core, a new product in the MusclePharm line of health supplements.
Having a body that naturally and efficiently burns fat sounds great. But MusclePharm Carnitine Core is a liquid dietary supplement, not a true diet pill. Can it really deliver results in just a few tablespoons a day? I looked into MusclePharm Carnitine Core to find out.
In addition to promising to transform bodies into fat-burning machines, MusclePharm Carnitine Core emphasizes several other advantages of its formula. For instance, MusclePharm Carnitine Core provides increased energy without stimulants.
MusclePharm Carnitine Core also claims to use a “balanced formula.” Unfortunately, the website doesn’t clarify what balanced means. My best guess is that it refers to the several types of carnitine in MusclePharm Carnitine Core, but I’m not certain.
The MusclePharm Carnitine Core formula uses four types of carnitine, along with raspberry ketone, to increase the body’s ability to convert fat into useable energy.
The amino acid compound carnitine is produced by the human body and found primarily in skeletal muscle. It plays an important role in the oxidizing, or burning, of fat. No scientific evidence proves carnitine induces weight loss, however. 
The alleged advantage of N-acetyl-L-carnitine is a greater bioavailability that other forms of carnitine.  But scientists are not sure if or how this type of carnitine is more easily processed by the body.
One 6-month study of L-carnitine-L-tartrate showed increases in muscle carnitine levels, as well as improved muscle metabolism.  But this study didn’t measure weight loss.
The last of MusclePharm Carnitine Core’s four types of carnitine, propionyl-L-carnitine was linked in one study to increased energy for athletic performance.  But like all other types of carnitine, it isn’t proven to cause weight loss.
Raspberry ketone is one of the most popular diet pill ingredients of recent years. This popularity stems from a few studies where mice lost weight with the help of raspberry ketones. Human studies are much less promising.
Since neither carnitine nor raspberry ketone are proven to enhance weight loss, I’m not sure MusclePharm Carnitine Core is a powerful diet pill alternative. The various forms of carnitine might decrease exercise fatigue or improve muscle composition after lengthy supplementation. But I need more scientific proof before I’ll believe MusclePharm Carnitine Core can greatly assist in weight loss.
Sometimes customer reviews of a product can fill in the gaps left by science. Lucky for MusclePharm Carnitine Core, it does have a small number of positive reviews online. Commenters noticed losing fat and having more energy to work out.
But none of these reviewers reported significant weight loss. Granted, MusclePharm Carnitine Core has only been available for a few months. I recommend looking for further reviews of this product if you’re trying to use it as a weight loss supplement.
Purchase and Use
For a relatively new product, MusclePharm Carnitine Core is available at surprising number of retailers. Often when a product first goes on sale, its makers limit the places it can be purchased in order to regulate the price. I’m pleased to see that’s not the case with MusclePharm Carnitine Core.
I found MusclePharm Carnitine Core for sale at the following websites for the listed prices:
• MusclePharm.com: $14.94
• BodyBuilding.com: $14.94
• Netrition.com: $12.99
• RedZoneSupps.com: $14.99
• NaperNutrition.com: $13.99
• ProSource.net: $12.99
• MuscleAndStrength.com: $13.99
When compared to other carnitine weight loss options, MusclePharm Carnitine Core is generally cheaper. For people who want to test the benefits of carnitine, MusclePharm Carnitine Core could be a cost effective option.
MusclePharm Carnitine Core comes in bottles with 16 fluid ounces of concentrated Carnitine Core Blend. One bottle contains 30 servings. Currently, the only flavor available is citrus.
A serving of MusclePharm Carnitine Core is one tablespoon of the liquid. This can be taken plain or mixed into juice or another liquid. Up to 3 servings can be taken in a 24-hour period. However, the instructions are not clear on whether it is safe to take these all at once or if they need to be spaced out.
Remember to shake the bottle before pouring and keep it in the refrigerator after opening.
MusclePharm Carnitine Core’s ingredients simply do not support its claim that it can turn your body into a fat-burning machine. Yes, carnitine plays an essential role in converting stored fat into energy. But so far, scientists can’t prove that taking carnitine supplements improves the body’s ability to burn fat. If weight loss is your goal, I recommend looking for a product other than MusclePharm Carnitine Core.
 “Carnitine (L-carnitine).” University of Maryland Medical Center. 2011. Available from: http://www.umm.edu/altmed/articles/carnitine-l-000291.htm
 Higdon J. “L-Carnitine.” Linus Pauling Institute, Oregon State University. 2002 Oct. Available from: http://lpi.oregonstate.edu/infocenter/othernuts/carnitine/
 Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff, PL. “Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans.” J Physiol. 2011 Feb 15. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060373/
 Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJ. “Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males.” J Int Soc Sports Nutr. 2009 Apr 2. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19341458
“Are you ready to look as good as you feel?” asks the commercial for Gaspari Detonate.
According to Gaspari, Detonate “is the real deal ladies and gentlemen and is far beyond just another over caffeinated version of everything else.”
Can Gaspari Detonate really blast off your fat and increase your energy?
Who Is Gaspari?
Gaspari Nutrition was founded by former bodybuilding champion Rich Gaspari, who wanted to carry his passion for bodybuilding and fitness into his own company.
This company’s mission is to “develop the most useful and effective products in their respective categories while breaking new ground with exciting categories never before seen.”
The company has over 270,000 Facebook likes, and its products are well received in outlets such as Amazon.com and BodyBuilding.com. They also have an A+ rating from the Better Business Bureau.
What’s in Gaspari Detonate?
Gaspari Nutrition seems like a reliable company. But do the ingredients in Gaspari Detonate give this product a good name? Let’s take a closer look.
Detonate Proprietary Blend (700 mg)
Dendrobium Extract (stem). Dendrobium is recently popular for its ability to boost athletic performance. Dendrobium’s stimulating chemicals may lower blood pressure as well.
However, there is some concern that products with dendrobium may be spiked with dangerous stimulants, like the fat burner Craze by Driven Sports. Even without the stimulating drugs, dendrobium may also increase chance of seizure.
B-Phenylethylamine HCL. This alkaloid functions as both a stimulant and a neurotransmitter. By releasing noradrenaline and dopamine, phenylethylamine increases exercise performance and mood. But side effects may include increased heart rate, headache, and dizziness.
Tangerine Extract (fruit). Tangerine might not seem like a fat burner, but a compound in tangerine, nobletin, may prevent weight gain. Tangerine seeds may also decrease cholesterol and regulate energy.
Caffeine Anhydrous. Unlike tangerine, caffeine is a veteran fat burner. This is because it has a powerful effect on the heart and body, increasing metabolism, energy, and fat burning. Unfortunately, caffeine could also increase heart rate and cause jitteriness, insomnia, and other side effects.
Green Tea Extract (leaf). When paired with caffeine, green tea assists weight loss through thermogenesis and fat oxidation. In one particular study, green tea improved weight management in overweight and obese subjects who were low caffeine consumers.  During a post-weight loss phase of three months, the subjects continued to lose weight with the help of green tea.
Green Coffee Bean Extract. The chlorogenic acid in green coffee bean extract slows glucose release in the body. Preliminary studies show it reduces weight in pre-obese adults and thus prevents obesity. However, additional studies are needed to confirm these results.
Asian Ginseng (root). In traditional Chinese medicine, Asian ginseng is used to induce calmness. In western medicine, however, it’s used as a stimulant. Ginseng is touted to increase stamina and endurance and to improve overall well-being. But it could cause insomnia, increased heart rate, dizziness, and other side effects.
Black Pepper Extract (BioPerine). BioPerine increases the absorbency and effectiveness of ingredients in Gaspari Detonate.
Using Gaspari Detonate
Manufacturers recommend taking one to two capsules on an empty stomach before breakfast. Start out with one capsule for the first three days and add another capsule if well tolerated.
The following warnings are issued by Gaspari about Detonate:
• Do not use it for longer than four weeks, with a four week break.
• Do not exceed two capsules in 24 hours.
• Consume at least 125 fl. oz. of water (men) or 91 fl. oz. of water (women) while taking Detonate.
• Do not take if you are under 18, pregnant or nursing, taking medications, have medical conditions, or are sensitive to caffeine.
• Do not take caffeine, stimulants, or alcohol while taking Detonate.
• Discontinue use if you experience side effects.
Gaspari Detonate: Take It or Leave It?
Gaspari Detonate comes from a good company and has ingredients that may allow for some weight loss. Unfortunately, the potential for side effects just don’t make it worth it.
If you do decide to try Gaspari Detonate, you can find it at the following locations:
• GaspariNutrition.com: $44.19
• BodyBuilding.com: $36.77
• Amazon.com: $26.53
If you’ve taken Gaspari Detonate, leave a comment and let us know how it worked for you.
 Margriet S. Westerterp-Plantenga; Manuela P.G.M. Lejeune; Eva M. R. Kovacs. “Body Weight and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation.” Obesity Research. 2005; 13 (7): 1195-1204. Available from: http://onlinelibrary.wiley.com/doi/10.1038/oby.2005.142/full